BE
Jupiler League
| Fri | 10-12-2021 | 20:45 | RSC Charleroi | KV Oostende |
| Sat | 11-12-2021 | 16:15 | KV Kortrijk | OH Leuven |
| Sat | 11-12-2021 | 18:30 | Sint-Truidense | Cercle Brugge |
| Sat | 11-12-2021 | 18:30 | KAS Eupen | Beerschot-Wilri |
| Sat | 11-12-2021 | 20:45 | RFC Seraing | RSC Anderlecht |
| Sun | 12-12-2021 | 13:30 | Antwerp | Standard Ličge |
| Sun | 12-12-2021 | 16:00 | Royale Union St | KV Mechelen |
| Sun | 12-12-2021 | 18:30 | KAA Gent | KRC Genk |
| Sun | 12-12-2021 | 21:00 | Club Brugge | SV Zulte Warege |
EN
Premier League
| Fri | 10-12-2021 | 21:00 | Brentford | Watford |
| Sat | 11-12-2021 | 13:30 | Manchester City | Wolves |
| Sat | 11-12-2021 | 16:00 | Arsenal | Southampton |
| Sat | 11-12-2021 | 16:00 | Chelsea | Leeds |
| Sat | 11-12-2021 | 16:00 | Liverpool | Aston Villa |
| Sat | 11-12-2021 | 18:30 | Norwich City | Manchester Unit |
| Sun | 12-12-2021 | 15:00 | Brighton and Ho | Tottenham Hotsp |
| Sun | 12-12-2021 | 15:00 | Burnley | West Ham United |
| Sun | 12-12-2021 | 15:00 | Leicester City | Newcastle Unite |
FR
Ligue 1
| Fri | 10-12-2021 | 21:00 | FC Nantes | RC Lens |
| Sat | 11-12-2021 | 17:00 | Stade Brest 29 | Montpellier HSC |
| Sat | 11-12-2021 | 21:00 | Stade Reims | AS Saint-Étienn |
| Sun | 12-12-2021 | 13:00 | Lille OSC | Lyon |
| Sun | 12-12-2021 | 15:00 | Angers SCO | Clermont Foot |
| Sun | 12-12-2021 | 15:00 | FC Metz | FC Lorient |
| Sun | 12-12-2021 | 15:00 | Stade Rennais F | OGC Nice |
| Sun | 12-12-2021 | 15:00 | ESTAC Troyes | Girondins Borde |
| Sun | 12-12-2021 | 17:00 | Strasbourg | Olympique Marse |
GE
Bundesliga
| Fri | 10-12-2021 | 20:30 | 1.FC Köln | FC Augsburg |
| Sat | 11-12-2021 | 15:30 | Bayern München | 1.FSV Mainz 05 |
| Sat | 11-12-2021 | 15:30 | RB Leipzig | Borussia Mönche |
| Sat | 11-12-2021 | 15:30 | SC Freiburg | TSG 1899 Hoffen |
| Sat | 11-12-2021 | 15:30 | Hertha BSC | Arminia Bielefe |
| Sat | 11-12-2021 | 15:30 | VfL Bochum | Borussia Dortmu |
| Sat | 11-12-2021 | 18:30 | VfL Wolfsburg | VfB Stuttgart |
| Sun | 12-12-2021 | 15:30 | SpVgg Greuther | 1.FC Union Berl |
| Sun | 12-12-2021 | 17:30 | Eintracht Frank | Bayer Leverkuse |
IT
Serie A
| Fri | 10-12-2021 | 20:45 | Genoa CFC | Sampdoria |
| Sat | 11-12-2021 | 15:00 | Fiorentina ACF | Salernitana |
| Sat | 11-12-2021 | 18:00 | Venezia | Juventus |
| Sat | 11-12-2021 | 20:45 | Udinese Calcio | AC Milan |
| Sun | 12-12-2021 | 12:30 | FC Torino | Bologna FC |
| Sun | 12-12-2021 | 15:00 | Hellas Verona F | Atalanta Bergam |
| Sun | 12-12-2021 | 18:00 | Napoli | Empoli FC |
| Sun | 12-12-2021 | 18:00 | Sassuolo | Lazio Roma |
| Sun | 12-12-2021 | 20:45 | Inter Milan | Cagliari Calcio |
NL
Eredivisie
| Fri | 10-12-2021 | 20:00 | Willem II | SC Cambuur |
| Sat | 11-12-2021 | 18:45 | FC Utrecht | Go Ahead Eagles |
| Sat | 11-12-2021 | 20:00 | SC Heerenveen | Sparta Rotterda |
| Sat | 11-12-2021 | 21:00 | PEC Zwolle | Fortuna Sittard |
| Sun | 12-12-2021 | 12:15 | FC Twente | RKC Waalwijk |
| Sun | 12-12-2021 | 14:30 | FC Groningen | Feyenoord |
| Sun | 12-12-2021 | 14:30 | Vitesse | Heracles Almelo |
| Sun | 12-12-2021 | 16:45 | Ajax | AZ |
| Sun | 12-12-2021 | 20:00 | NEC | PSV |
PO
Superliga
| Sun | 12-12-2021 | 19:00 | Sporting Lisbon | Boavista FC |
| Sun | 12-12-2021 | 19:00 | FC Porto | Sporting Braga |
| Sun | 12-12-2021 | 19:00 | Paços de Ferrei | Gil Vicente FC |
| Sun | 12-12-2021 | 19:00 | Vitória de Guim | CD Tondela |
| Sun | 12-12-2021 | 19:00 | Moreirense FC | Portimonense SC |
| Sun | 12-12-2021 | 19:00 | FC Famalicăo | Benfica S.L. |
| Sun | 12-12-2021 | 19:00 | Belenenses CF | Estoril Praia G |
| Sun | 12-12-2021 | 19:00 | Maritimo | Santa Clara |
| Sun | 12-12-2021 | 19:00 | FC Arouca | FC Vizela |
RU
Premier Liga 1
| Fri | 10-12-2021 | 18:00 | FC Rostov | Ural |
| Fri | 10-12-2021 | 18:00 | Krasnodar | Nizhny Novgorod |
| Fri | 10-12-2021 | 18:00 | Krylya Sovetov | Rubin Kazan |
| Fri | 10-12-2021 | 18:00 | CSKA Moscow | FK Arsenal Tula |
| Fri | 10-12-2021 | 18:00 | Dynamo Moscow F | Zenit St Peters |
| Fri | 10-12-2021 | 18:00 | Lokomotiv Moskv | Ufa |
| Fri | 10-12-2021 | 18:00 | Akhmat Grozny | Khimki |
| Fri | 10-12-2021 | 18:00 | PFC Sochi | FC Spartak Mosk |
| Fri | 25-02-2022 | 18:00 | Zenit St Peters | Rubin Kazan |
SC
Premier League
| Sat | 11-12-2021 | 16:00 | Celtic FC | Motherwell FC |
| Sat | 11-12-2021 | 16:00 | Dundee United | Livingston |
| Sat | 11-12-2021 | 16:00 | Heart of Midlot | Rangers FC |
| Sat | 11-12-2021 | 16:00 | Ross County FC | Dundee FC |
| Sat | 11-12-2021 | 16:00 | St. Johnstone | Aberdeen |
| Sat | 11-12-2021 | 16:00 | St Mirren | Hibernian FC |
| Sat | 18-12-2021 | 16:00 | Dundee FC | Heart of Midlot |
| Sat | 18-12-2021 | 16:00 | Hibernian FC | Aberdeen |
| Sat | 18-12-2021 | 16:00 | Livingston | Ross County FC |
SP
Primera Division
| Fri | 10-12-2021 | 21:00 | Real Club Depor | Celta de Vigo |
| Sat | 11-12-2021 | 14:00 | Espanyol de Bar | Levante UD |
| Sat | 11-12-2021 | 16:15 | Deportivo Alavé | Getafe CF |
| Sat | 11-12-2021 | 18:30 | Valencia | Elche CF |
| Sat | 11-12-2021 | 21:00 | Athletic Bilbao | Sevilla FC |
| Sun | 12-12-2021 | 14:00 | Villarreal CF | Rayo Vallecano |
| Sun | 12-12-2021 | 16:15 | CA Osasuna | FC Barcelona |
| Sun | 12-12-2021 | 18:30 | Real Betis | Real Sociedad |
| Sun | 12-12-2021 | 21:00 | Real Madrid | Atletico Madrid |
US
Major League
| Mon | 08-11-2021 | Sporting Kansas | Real Salt Lake | 0 - 1 |
| Mon | 08-11-2021 | Colorado Rapids | Los Angeles FC | 5 - 2 |
| Mon | 08-11-2021 | LA Galaxy | Minnesota Unite | 3 - 3 |
| Mon | 08-11-2021 | San Jose Earthq | FC Dallas | 1 - 1 |
| Mon | 08-11-2021 | Portland Timber | Austin FC | 3 - 0 |
| Mon | 08-11-2021 | Vancouver White | Seattle Sounder | 1 - 1 |
| Sun | 07-11-2021 | New England Rev | Inter Miami CF | 0 - 1 |
| Sun | 07-11-2021 | CF Montreal | Orlando City SC | 0 - 2 |
| Sun | 07-11-2021 | New York City F | Philadelphia Un | 1 - 1 |
