BE
Jupiler League
| Fri | 22-10-2021 | 20:45 | RFC Seraing | RSC Charleroi |
| Sat | 23-10-2021 | 16:15 | Cercle Brugge | Standard Ličge |
| Sat | 23-10-2021 | 18:30 | KV Kortrijk | KV Oostende |
| Sat | 23-10-2021 | 18:30 | KV Mechelen | SV Zulte Warege |
| Sat | 23-10-2021 | 20:45 | KAS Eupen | Royale Union St |
| Sun | 24-10-2021 | 13:30 | Antwerp | Club Brugge |
| Sun | 24-10-2021 | 16:00 | RSC Anderlecht | Beerschot-Wilri |
| Sun | 24-10-2021 | 18:30 | KRC Genk | KAA Gent |
| Sun | 24-10-2021 | 21:00 | OH Leuven | Sint-Truidense |
EN
Premier League
| Fri | 22-10-2021 | 21:00 | Arsenal | Aston Villa |
| Sat | 23-10-2021 | 13:30 | Chelsea | Norwich City |
| Sat | 23-10-2021 | 16:00 | Crystal Palace | Newcastle Unite |
| Sat | 23-10-2021 | 16:00 | Everton | Watford |
| Sat | 23-10-2021 | 16:00 | Leeds | Wolves |
| Sat | 23-10-2021 | 16:00 | Southampton | Burnley |
| Sat | 23-10-2021 | 18:30 | Brighton and Ho | Manchester City |
| Sun | 24-10-2021 | 15:00 | Brentford | Leicester City |
| Sun | 24-10-2021 | 15:00 | West Ham United | Tottenham Hotsp |
FR
Ligue 1
| Fri | 22-10-2021 | 21:00 | AS Saint-Étienn | Angers SCO |
| Sat | 23-10-2021 | 17:00 | FC Nantes | Clermont Foot |
| Sat | 23-10-2021 | 21:00 | Lille OSC | Stade Brest 29 |
| Sun | 24-10-2021 | 13:00 | OGC Nice | Lyon |
| Sun | 24-10-2021 | 15:00 | RC Lens | FC Metz |
| Sun | 24-10-2021 | 15:00 | FC Lorient | Girondins Borde |
| Sun | 24-10-2021 | 15:00 | Stade Reims | ESTAC Troyes |
| Sun | 24-10-2021 | 15:00 | Stade Rennais F | Strasbourg |
| Sun | 24-10-2021 | 17:00 | AS Monaco | Montpellier HSC |
GE
Bundesliga
| Fri | 22-10-2021 | 20:30 | 1.FSV Mainz 05 | FC Augsburg |
| Sat | 23-10-2021 | 15:30 | Bayern München | TSG 1899 Hoffen |
| Sat | 23-10-2021 | 15:30 | RB Leipzig | SpVgg Greuther |
| Sat | 23-10-2021 | 15:30 | VfL Wolfsburg | SC Freiburg |
| Sat | 23-10-2021 | 15:30 | Arminia Bielefe | Borussia Dortmu |
| Sat | 23-10-2021 | 18:30 | Hertha BSC | Borussia Mönche |
| Sun | 24-10-2021 | 15:30 | 1.FC Köln | Bayer Leverkuse |
| Sun | 24-10-2021 | 17:30 | VfB Stuttgart | 1.FC Union Berl |
| Sun | 24-10-2021 | 19:30 | VfL Bochum | Eintracht Frank |
IT
Serie A
| Fri | 22-10-2021 | 18:30 | FC Torino | Genoa CFC |
| Fri | 22-10-2021 | 20:45 | Sampdoria | Spezia |
| Sat | 23-10-2021 | 15:00 | Salernitana | Empoli FC |
| Sat | 23-10-2021 | 18:00 | Sassuolo | Venezia |
| Sat | 23-10-2021 | 20:45 | Bologna FC | AC Milan |
| Sun | 24-10-2021 | 12:30 | Atalanta Bergam | Udinese Calcio |
| Sun | 24-10-2021 | 15:00 | Fiorentina ACF | Cagliari Calcio |
| Sun | 24-10-2021 | 15:00 | Hellas Verona F | Lazio Roma |
| Sun | 24-10-2021 | 18:00 | AS Roma | Napoli |
NL
Eredivisie
| Fri | 22-10-2021 | 20:00 | Willem II | Fortuna Sittard |
| Sat | 23-10-2021 | 18:45 | FC Utrecht | SC Heerenveen |
| Sat | 23-10-2021 | 20:00 | PEC Zwolle | Heracles Almelo |
| Sat | 23-10-2021 | 21:00 | RKC Waalwijk | Sparta Rotterda |
| Sun | 24-10-2021 | 12:15 | FC Twente | NEC |
| Sun | 24-10-2021 | 14:30 | SC Cambuur | Feyenoord |
| Sun | 24-10-2021 | 14:30 | Vitesse | Go Ahead Eagles |
| Sun | 24-10-2021 | 16:45 | Ajax | PSV |
| Sun | 24-10-2021 | 20:00 | FC Groningen | AZ |
PO
Superliga
| Fri | 22-10-2021 | 21:15 | Vitória de Guim | Maritimo |
| Sat | 23-10-2021 | 16:30 | Santa Clara | FC Famalicăo |
| Sat | 23-10-2021 | 19:00 | CD Tondela | FC Porto |
| Sat | 23-10-2021 | 21:30 | Sporting Lisbon | Moreirense FC |
| Sun | 24-10-2021 | 16:30 | Paços de Ferrei | FC Arouca |
| Sun | 24-10-2021 | 19:00 | FC Vizela | Benfica S.L. |
| Sun | 24-10-2021 | 21:30 | Portimonense SC | Estoril Praia G |
| Mon | 25-10-2021 | 20:00 | Gil Vicente FC | Sporting Braga |
| Mon | 25-10-2021 | 22:15 | Boavista FC | Belenenses CF |
RU
Premier Liga 1
| Fri | 22-10-2021 | 19:00 | Zenit St Peters | FC Spartak Mosk |
| Fri | 22-10-2021 | 19:00 | FC Rostov | FK Arsenal Tula |
| Fri | 22-10-2021 | 19:00 | CSKA Moscow | Krylya Sovetov |
| Fri | 22-10-2021 | 19:00 | Dynamo Moscow F | Khimki |
| Fri | 22-10-2021 | 19:00 | Lokomotiv Moskv | PFC Sochi |
| Fri | 22-10-2021 | 19:00 | Akhmat Grozny | Ural |
| Fri | 22-10-2021 | 19:00 | Nizhny Novgorod | Krasnodar |
| Fri | 22-10-2021 | 19:00 | Ufa | Rubin Kazan |
| Fri | 29-10-2021 | 19:00 | Zenit St Peters | Dynamo Moscow F |
SC
Premier League
| Sat | 23-10-2021 | 16:00 | Aberdeen | Hibernian FC |
| Sat | 23-10-2021 | 16:00 | Celtic FC | St. Johnstone |
| Sat | 23-10-2021 | 16:00 | Dundee United | Motherwell FC |
| Sat | 23-10-2021 | 16:00 | Heart of Midlot | Dundee FC |
| Sat | 23-10-2021 | 16:00 | Ross County FC | Livingston |
| Sat | 23-10-2021 | 16:00 | St Mirren | Rangers FC |
| Wed | 27-10-2021 | 20:45 | Dundee FC | Ross County FC |
| Wed | 27-10-2021 | 20:45 | Hibernian FC | Celtic FC |
| Wed | 27-10-2021 | 20:45 | Livingston | Dundee United |
SP
Primera Division
| Fri | 22-10-2021 | 21:00 | CA Osasuna | Granada CF |
| Sat | 23-10-2021 | 14:00 | Valencia | Real Club Depor |
| Sat | 23-10-2021 | 16:15 | Cádiz CF | Deportivo Alavé |
| Sat | 23-10-2021 | 18:30 | Elche CF | Espanyol de Bar |
| Sat | 23-10-2021 | 21:00 | Athletic Bilbao | Villarreal CF |
| Sun | 24-10-2021 | 14:00 | Sevilla FC | Levante UD |
| Sun | 24-10-2021 | 16:15 | FC Barcelona | Real Madrid |
| Sun | 24-10-2021 | 18:30 | Real Betis | Rayo Vallecano |
| Sun | 24-10-2021 | 21:00 | Atletico Madrid | Real Sociedad |
US
Major League
| Wed | 20-10-2021 | 06:00 | Inter Miami CF | Toronto FC |
| Thu | 21-10-2021 | 01:30 | Orlando City SC | CF Montreal |
| Thu | 21-10-2021 | 01:30 | Atlanta United | New York City F |
| Thu | 21-10-2021 | 01:30 | FC Cincinnati | Chicago Fire |
| Thu | 21-10-2021 | 02:00 | DC United | New England Rev |
| Thu | 21-10-2021 | 02:00 | Minnesota Unite | Philadelphia Un |
| Thu | 21-10-2021 | 02:00 | FC Dallas | Los Angeles FC |
| Thu | 21-10-2021 | 02:30 | Nashville SC | Columbus Crew |
| Thu | 21-10-2021 | 02:30 | Houston Dynamo | LA Galaxy |
